Glibenclamide reduces secondary brain damage after experimental traumatic brain injury

Katharina Hackenberg, Klaus Zweckberger, Oliver W. Sakowitz, Carla S. Jung & Andreas W. Unterberg
Objective: The Sulfonylurea receptor 1 (SUR1) regulates non-selective cation channels in ischemic astrocytes, neurons and endothelial cells. Blocking of SUR1 with low-dose glibenclamide reduces cerebral edema, infarct volume and mortality rate in models of experimental cerebral stroke and subarachnoid[for full text, please go to the a.m. URL]