5-Lipoxygenase inhibitors alter the spatiotemporal profile of infiltrating macrophages and granulocytes when given prior to experimental traumatic brain injury

Martin U. Schuhmann, Dominik Michalski, Gudrun Seeger, Cornelia Voigt & Wolfgang Härtig
Objective: Traumatic brain injury (TBI) typically causes an inflammatory response, which is considered as a significant contributor to neuronal death with consecutive poor outcome. Recently, we showed in a rat model of controlled cortical impact (CCI) that leukotriene inhibitors (LIs) could attenuate[for full text, please go to the a.m. URL]