Atypical chordoma with loss of SMARCB1/INI1 expression: report of 3 different clinical courses in pediatric patients

Mario Mühmer, Jörg Felsberg, Thomas Beez, Gisela Janßen, Hans-Jakob Steiger & Sevgi Sarikaya-Seiwert
Objective: Chordoma is a rare, potentially malignant neoplasm, believed to derive from the fetal notochord affecting adults primarily. It occurs in the whole neuroaxis, but is mainly seen in the clival or sacral area. For poorly differentiated chordoma, loss of expression of SMARCB1/INI1, a possible[for full text, please go to the a.m. URL]