The unique angiogenic response of endothelial cells derived from human CCMs (CCM-ECs) to silencing CCM1-3 genes

Yuan Zhu, Qun Wu, Jin-Fang Xu, I. Erol Sandalcioglu & Ulrich Sure
Objective: Loss-of-function mutations in CCM genes are frequently detected in familial cerebral cavernous malformations (CCMs). However, the current functional studies on CCM genes have been performed mostly in commercial purchased cell lines and the results appeared discrepancy. We assumed that silencing[for full text, please go to the a.m. URL]