Protoporphyrin IX fluorescence and photobleaching during interstitial photodynamic therapy of malignant gliomas for early treatment prognosis

Florian Faber, Ann Johansson, Herbert Stepp, Ronald Sroka, Wolfgang Beyer & Friedrich-Wilhelm Kreth
Objective: Interstitial photodynamic therapy (iPDT) of non-resectable glioblastoma-recurrences using 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) appears to be promising. It remained unclear, however, to which extent inter- and intra-tumoral differences of PpIX concentrations influence[for full text, please go to the a.m. URL]