mTOR-inihibition and interruption of PI3K/Akt signaling leads to proliferation inhibition and induces apoptosis with defective autophagy in human meningioma cells

Jan Walter, Alina Sophie Krombholz, Susanne Grube, Diana Freitag, Rolf Kalff & Christian Ewald
Objective: The PI3K/Akt signaling pathway and its downstream effector mTOR are known to play an important role in the regulation of cell growth and have recently been evaluated as a target for the treatment of a variety of tumors. Increasing evidence suggests its involvement in glioma cell survival,[for full text, please go to the a.m. URL]