Methylation-specific multiplex ligation-dependent probe amplification and its possible impact on clinical findings in juvenile medulloblastomas

Denise Feierabend, Jan Walter, Christian Beetz, Rolf Kalff & Christian Ewald
Objective: Gain of (proto-)oncogenes and loss of or promotor methylation of tumor suppressor gene (TSG) are considered to play an essential role in tumor genesis and progression. Methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) allows the simultaneous detection of both[for full text, please go to the a.m. URL]