Cell culture studies of 5-ALA uptake and metabolism in gliomas

Andrei Nemes, Volker Senner, Walter Stummer & Christian Ewelt
Objective: For several years 5-Aminolevulinic acid (5-ALA) induced Protoporhyrin IX (PPIX) fluorescence in malignant brain tumors has been used as an intraoperative marker to improve the grade of total resection. Despite that application, key questions concerning e.g. the heterogenous accumulation of[for full text, please go to the a.m. URL]