Development and evaluation of an electrochemical nitric oxide sensing on-chip cell culture system for measurement of pericellular NO in glioma cell cultures

Nadja Osterberg, Kuppusamy Aravindalochanan, Jochen Kieninger, Gerald A. Urban & Astrid Weyerbrock
Objective: Nitric oxide (NO) plays a crucial role in multiple cancer signalling pathways and its antitumor effects are studied in various cancers including malignant gliomas. To assess pericellular NO levels after exogenous NO administration in glioma cell cultures, we developed an electrochemical NO[for full text, please go to the a.m. URL]