Inhibition of mitotic Aurora B led to disturbed chromosomal segregation and mitotic catastrophe in glioma cells irrespective of 53 status

Ralf Wiedemuth, Gabriele Schackert & Achim Temme
Objective: Inhibition of Aurora kinase B by RNA interference or small chemical compounds has been shown to block solid tumor growth in many different tumor entities even in gliomas. In this study we sought to elucidate the role of the tumor suppressor protein p53 in the cell cycle regulation and chromosomal[for full text, please go to the a.m. URL]