Problems in the assessment of diagnostic test validity of already established biomarkers – a simulation study using the example of 14-3-3 in sporadic Creutzfeldt-Jakob disease

André Karch, Inga Zerr & Annika Müller-Heine
Background: Whereas a definite diagnosis of neuro-degenerative diseases can be obtained in post-mortem autopsies only, diagnosis during lifetime is less valid and typically based on a combination of diagnostic criteria, including cerebrospinal (CSF) biomarkers. A classic example is the use of proteins[for full text, please go to the a.m. URL]