Alterations in the expression patterns of Akt and p-Akt in the cochlea of the guinea pig after intratympanic application of gentamicin

Ulf-Rüdiger Heinrich, Jürgen Brieger, Sebastian Elsner, Irene Schmidtmann, Wolf Jürgen Mann & Kai Helling
Objective: The therapeutic application of gentamicin generally induces numerous different, partly contrary, biochemical processes. Besides apoptosis and resulting cell death, there is some evidence for the induction of cell protecting mechanisms in which proteine kinase B (Akt) is involved. The aim [for full text, please go to the a.m. URL]