Pax2 and Sox2 cooperate to activate expression of Atoh1

Judith Kempfle & Albert Edge
Introduction: Sensorineural hearing loss (SNHL) is a common problem of our generation and has increased over the last decades. Normal function of inner ear hair cells is crucial for hearing. In mammals, inner ear hair cells cannot regenerate after damage. A single transcription factor, Atoh1, is essential[for full text, please go to the a.m. URL]