Inactivation of HIF1a and VEGFA in myeloid cells reduces retinal and choroidal neovascularisation

Clemens Lange, A. Fantin, L. Denti, A. J. Smith, R.R. Ali, C. Ruhrberg & J.W. Bainbridge
Myeloid cells have been implicated in retinal and choroidal neovascularization in sight-threatening neovascular eye diseases such as diabetic retinopathy and age-related macular degeneration. The hypoxia-inducible transcription factor 1 alpha (HIF1A) is activated by inflammatory stimuli and hypoxia [for full text, please go to the a.m. URL]