Janus face-like effects of Aurora B inhibition: Anti-glioma mode of action versus induction of chromosomal instability

Achim Temme, Ralf Wiedemuth, Marina Conde, Barbara Klink, Evelin Schröck & Gabriele Schackert
Objective: The mitotic Aurora B kinase is overexpressed in various cancers and several inhibitors for Aurora B are currently under clinical assessments. Yet, the precise mode of the anti-tumoral action of Aurora B inhibitors and the possible impact of p53 on treatment remained unclear. In this study,[for full text, please go to the a.m. URL]
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