APOE signaling is a common pathway in microglia in neurodegeneration

Susanne Krasemann, Charlotte Madore, Elaine O´Loughlin, Ron Cialic, Zain Fanek, Rachid El Fatimy, David Greco, Scott Smith, Georg Tweet, Fargol Mazaheri, Patricia Conde-Sanroman, Mar Garcias, Narghes Calcagno, Markus Glatzel, Anna Worthmann, Joerg Heeren, Cynthia Lemere, Charles Vanderburg, Frank Heppner, Bogdan Budnik, Tsuneya Ikezu, Hans Lassmann, Howard Weiner, Jordi Ochando, Christian Haass … & Oleg Butovsky
Microglia are the immune cells of the brain. They play a dual role by promoting homeostatic functions in the healthy brain, but acquiring dysregulated properties in neurodegenerative and neuroinflammatory diseases. How this switch in the microglia phenotype is executed on the molecular level is still[for full text, please go to the a.m. URL]
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