Synaptic pruning and microglia in Phenylketonuria

Gudrun Schlegel & Gabriele M. Rune
Mutations of the enzyme phenylalanine hydroxylase result in elevated levels of the amino acid phenylalanine (Phe) in blood and cerebrospinal fluid causing the metabolic disorder Phenylketonuria (PKU). In the hippocampus of the mouse model Pahenu2, we found disturbed synaptic pruning resulting in an [for full text, please go to the a.m. URL]
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