ALS-linked mutant Sigma receptor-1 leads to defects in protein homeostasis and dysregulation of RNA binding proteins

Alice Dreser, Antonio Sechi, Saeed Bohlega, Dirk Troost, Joachim Weis & Anand Goswami
Introduction: Misfolded proteins, which often form intracellular inclusion bodies, are a pathological hallmark of ALS. Disruption of the functional interplay between protein degradation (autophagy) and RNA processing has recently been proposed as an integrated model merging several ALS-associated genes[for full text, please go to the a.m. URL]
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