Genomic stratification by HLA-DRB4 expression identifies differential innate and adaptive immune patterns – A strategy to identify predictors of methotrexate response in early rheumatoid arthritis

Bruno Stuhlmüller, Karsten Mans, Neeraj Tandon, Marc Bonin, Biljana Smiljanovic, Till Sörensen, Pascal Schendel, Peter Martus, Joachim Listing, Jacqueline Detert, Marina Backhaus, Thomas Neumann, Gerd-Rüdiger Burmester & Thomas Häupl
Background: Selecting effective drugs for individual patients is the current challenge in rheumatoid arthritis (RA). When methotrexate (MTX) as first line drug fails, targeted therapies with different modes of action may be necessary. Thus, MTX response prediction in early RA provides the opportunity[for full text, please go to the a.m. URL]
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