Comparison of Neutrophilic Activation and Secretion of Cytokines derived from Patients with Familial Mediterranean Fever and other Acute and Chronic Inflammatory Diseases

Iris Stoler, Judith Freytag, Banu Orak, Christine Seib, Lars Esmann, Eva C. D. Seipelt, Faekah Gohar, Dirk Foell, Helmut Wittkowski & Tilmann Kallinich
Background: In Familiar Mediterranean Fever (FMF), the most common monogenic autoinflammatory disorder, gain-of-function mutations lead to an increased activation of the inflammasome. Neutrophils play a key role in the pathogenesis of FMF. Objectives: (i) To identify a FMF-specific genotype-dependent[for full text, please go to the a.m. URL]
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