Masticatory muscles show differential expression of MHC-isoforms in mdx-mice

Christiane Kunert-Keil, Alexander Spassov, Silke Lucke & Tomas Gedrange
Background: Duchenne Muscular Dystrophy (DMD) and its murine model, mdx, are characterized by Ca2+ induced muscle damage, fibrosis and muscle weakness. Furthermore, DMD patients have distorted dentofacial morphology which could be a result of changed masticatory mechanics due to muscular dysfunction. Aim: To determine potential changes in masticatory mechanics we searched for morphological abnormalities including nuclei localisation, fibre diameters and collagen expression and examined the expression of myosin heavy chain (MHC)-isoforms in control and mdx...