Pou4f3 mutant mice show stereocilia fusion and gaint stereocilia in auditory hair cells

Fang Wang
Introduction: An 8–base pair deletion in the exon 2 of human POU4F3 gene (c.884del8) was identified in Family H, which resulted in a truncated protein, impaired high-affinity binding in a dominant negative fashion, leading to inherited progressive hearing loss(DFNA15). Result: In this report, we generated heterozygous knockin mice by adding a mutant site containing a 8-bp deletion and a C-T interval in the end of exon 2 of Pou4f3 gene. The mutant mice displayed an...