Aminoglycoside-free interventional antibiotic management in patients undergoing haemopoietic stem cell transplantation

William H. Krüger, Thomas Kiefer, Georg Daeschlein, Ivo Steinmetz, Axel Kramer & Gottfried Dölken
The position of aminoglycosides within interventional antibiosis in the early phase after stem cell transplantation has not been fully clarified so far although their use can induce serious renal impairment. To investigate this question early-infection data from 152 patients undergoing 195 allogeneic and autologous stem cell transplantations were investigated. Prophylaxis and treatment of infections followed international standards; however, aminoglycosides were omitted to avoid additional risks such as ototoxicity and nephrotoxicity and increased selection of resistant...