High resistance of Pseudomonas aeruginosa to paromomycin, an agent used for selective bowel decontamination (SBD)

Florian Daxboeck, Werner Rabitsch, Maria Stadler, Ojan Assadian & Johannes Leitgeb
Background: Paromomycin is used for selective bowel decontamination (SBD) in patients undergoing bone marrow transplantation in many hospitals, but there are no published resistance data for this compound in the recent medical literature. The aim of this study was to investigate the in vitro activity of paromomycin against the common intestinal bacteria E. coli and P. aeruginosa. Methods: 94 E. coli isolates and 77 P. aeruginosa isolates derived from clinical specimens were tested by broth...