Human papillomavirus (HPV) vaccination for the prevention of HPV 16/18 induced cervical cancer and its precursors

Oliver Damm, Marc Nocon, Stephanie Roll, Christoph Vauth, Stefan Willich & Wolfgang Greiner
Introduction Essential precondition for the development of cervical cancer is a persistent human papillomavirus (HPV) infection. The majority - approximately 70% - of cervical carcinomas is caused by two high-risk HPV types (16 and 18). Recently, two vaccines have been approved to the German market with the potential to induce protection against HPV 16 and HPV 18 among additional low-risk virus types. Objectives To analyse whether HPV vaccination is effective with regard to the reduction...