Prognostic value, clinical effectiveness and cost-effectiveness of high sensitivity C-reactive protein as a marker in primary prevention of major cardiac events

Petra Schnell-Inderst, Ruth Schwarzer, Alexander Göhler, Norma Grandi, Kristin Grabein, Björn Stollenwerk, Volker Klauß, Jürgen Wasem & Uwe Siebert
Background In a substantial portion of patients (= 25%) with coronary heart disease (CHD), a myocardial infarction or sudden cardiac death without prior symptoms is the first manifestation of disease. The use of new risk predictors for CHD such as the high-sensitivity C-reactive Protein (hs-CRP) in addition to established risk factors could improve prediction of CHD. As a consequence of the altered risk assessment, modified preventive actions could reduce the number of cardiac death and...