Antibiotic therapy in Shiga toxin producing Escherichia coli infection and colonization

Johannes K.-M. Knobloch, Susanne Hauswaldt, Werner Solbach, Martin Nitschke & Friedhelm Sayk
The post diarrheal hemolytic uremic syndrome (HUS) is a major complication of enteric infections with Shiga toxin producing E. coli (STEC). According to the present recommendations, antibiotic therapy of acute bloody diarrhea caused by STEC is generally discouraged. These recommendations are based on historically conflicting results describing the potential induction of HUS by antibiotic treatment during the early phase of infection with enterohemorrhagic E. coli O157 whereas no guidelines are available for the use of...