BMP-2 shows characteristic extracellular patterns in osteoarthritic cartilage: a preliminary report

Julia K. Pester, Stephanie Stumpfe, Susanne Steinert, Ivan Marintschev, Matthias Aurich & Gunther O. Hofmann
To determine bone morphogenetic protein (BMP)-2 protein and Aggrecan in osteoarthritic and healthy cartilage with special regard to localization and degree of cartilage damage 95 samples representing osteoarthritic cartilage and 17 samples out of normal cartilage were graded histological by Mankin Score and were studied by immunohistochemistry for the expression of BMP-2 and Aggrecan. BMP-2 protein was detected intracellular in normal and in osteoarthritic cartilage. Extracellular BMP-2 was detected exclusively in osteoarthritic cartilage and exhibits...