Why we still don't understand the depressed brain – Not going beyond snapshots

Henrik Kessler, Harald Traue & Daniel Wiswede
Although remarkable progress has been made in the search for the brain correlates of depression with neuroimaging methods, we still find a heterogeneity of results and lack of consensus. This short commentary proposes a theoretical reason for this situation linking it to the methods of conducting neuroimaging studies of depression and the ways to interpret findings. If we only take one snapshot of the “depressed brain”, the brain activity is presumably the result of four...