This dataset provides Level 1 (L1) remotely sensed differential absorption optical depth (DAOD) measurements made through the Multi-Functional Fiber Laser Lidar (MFLL; Harris Corporation) during airborne campaigns in Summer 2016, Winter 2017, Fall 2017, and Spring 2018 conducted over central and eastern regions of the United States for the Atmospheric Carbon and Transport (ACT-America) project. DAOD were measured at 0.1 second frequency during flights of the C-130 Hercules aircraft at altitudes up to 8 km...