Charge-Mediated Recognition of N-Terminal Tryptophan in Aqueous Solution by a Synthetic Host

Meghan E. Bush, Nicole D. Bouley & Adam R. Urbach
The molecular recognition of peptides and proteins in aqueous solution by designed molecules remains an elusive goal with broad implications for basic biochemical research and for sensors and separations technologies. This paper describes the recognition of N-terminal tryptophan in aqueous solution by the synthetic host cucurbit[8]uril (Q8). Q8 is known to form 1:1:1 heteroternary complexes with methyl viologen (MV) and a second aromatic guest. Here, the complexes of Q8·MV with (i) the four natural aromatic...
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