Multianalyte Sensing of Addictive Over-the-Counter (OTC) Drugs

Tsuyoshi Minami, Nina A. Esipenko, Ali Akdeniz, Ben Zhang, Lyle Isaacs & Pavel Anzenbacher
A supramolecular sensor array composed of two fluorescent cucurbit[n]uril-type receptors (probe 1 and probe 2) displaying complementary selectivities was tested for its ability to detect and quantify drug-related amines. The fluorimetric titration of the individual probes showed highly variable and cross-reactive analyte-dependent changes in fluorescence. An excellent ability to recognize a variety of analytes was demonstrated in qualitative as well as quantitative assays. Importantly, a successful quantitative analysis of several analytes of interest was achieved...
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