Molecular Recognition of Methionine-Terminated Peptides by Cucurbit[8]uril

Zoheb Hirani, Hailey F. Taylor, Emily F. Babcock, Andrew T. Bockus, C. Daniel Varnado, Christopher W. Bielawski & Adam Urbach
This Article describes the molecular recognition of peptides containing an N-terminal methionine (Met) by the synthetic receptor cucurbit[8]uril (Q8) in aqueous solution and with submicromolar affinity. Prior work established that Q8 binds with high affinity to peptides containing aromatic amino acids, either by simultaneous binding of two aromatic residues, one from each of two different peptides, or by simultaneous binding of an aromatic residue and its immediate neighbor on the same peptide. The additional binding...
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