Analysis of the Inflammatory and Degenerative State of Osteoarthritic Joints

Development of disease modifying osteoarthritis drugs has been hindered by an inability to diagnose osteoarthritis prior to structural changes and by animal models that cannot predict human responses to disease modifying interventions. The first part of this dissertation evaluated if a novel nonsurgical-voluntary animal model was capable of producing joint inflammation and degeneration as well as if ibuprofen could attenuate these outcomes. Spraque-Dawley rats were divided among 7 groups. The four experimental groups consisted of...
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