THE EMERGING ROLE OF THE INTERACTION BETWEEN JUNCTOPHILIN-2 AND L-TYPE CALCIUM CHANNEL IN EXCITATION-CONTRACTION COUPLING MICRO-SIGNALING DOMAINS DURING CARDIAC PATHOLOGICAL REMODELING

Pathological cardiac remodeling is a set of cellular and molecular changes culminating in ventricular dysfunction, malignant arrhythmias and heart failure. Prominent effects of pathological cardiac remodeling include loss of transverse tubules (T-tubules) and disruption of cardiac dyads. The dyad composes the basic microstructural element in cardiomyocytes by forming a junctional complex, in which the T-tubular membrane and the junctional sarcoplasmic reticulum (jSR) membrane are brought into a close proximity. In this spatially restricted microdomain, the...
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