The P2Y(2) Nucleotide Receptor Mediates Tissue Factor Expression in Human Coronary Artery Endothelial Cells

Ling Ding, Wanshu Ma, Timothy Littmann, Riley Camp & Jianzhong Shen
The discovery of the role of P2Y12 receptor in platelet aggregation leads to a new anti-thrombotic drug Plavix; however, little is known about non-platelet P2Y receptors in thrombosis. This study tested the hypothesis that endothelial P2Y receptor(s) mediates up-regulation of tissue factor (TF), the initiator of coagulation cascade. Stimulation of human coronary artery endothelial cells (HCAEC) by UTP/ATP increased the mRNA level of TF but not of its counterpart-tissue factor pathway inhibitor, which was accompanied...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.