Genomic responses to selection for tame/aggressive behaviors in the silver fox (Vulpes vulpes)

Xu Wang, Lenore Pipes, Lyudmila N. Trut, Yury Herbeck, Anastasiya V. Vladimirova, Rimma G. Gulevich, Anastasiya V. Kharlamova, Jennifer L. Johnson, Gregory M. Acland, Anna V. Kukekova & Andrew G. Clark
Animal domestication efforts have led to a shared spectrum of striking behavioral and morphological changes. To recapitulate this process, silver foxes have been selectively bred for tame and aggressive behaviors for more than 50 generations at the Institute for Cytology and Genetics in Novosibirsk, Russia. To understand the genetic basis and molecular mechanisms underlying the phenotypic changes, we profiled gene expression levels and coding SNP allele frequencies in two brain tissue specimens from 12 aggressive...
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