HVEM Signalling Promotes Colitis

Corinne Schaer, Stefanie Hiltbrunner, Bettina Ernst, Christoph Mueller, Michael Kurrer, Manfred Kopf & Nicola L. Harris
Background Tumor necrosis factor super family (TNFSF) members regulate important processes involved in cell proliferation, survival and differentiation and are therefore crucial for the balance between homeostasis and inflammatory responses. Several members of the TNFSF are closely associated with inflammatory bowel disease (IBD). Thus, they represent interesting new targets for therapeutic treatment of IBD. Methodology/Principal Findings We have used mice deficient in TNFSF member HVEM in experimental models of IBD to investigate its role in...
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