Lung tissue remodeling in MCT-induced pulmonary hypertension: a proposal for a novel scoring system and changes in extracellular matrix and fibrosis associated gene expression

Marcus Franz, Katja Grün, Stefan Berge, Ilonka Rohm, Bernadin Ngongson-Dongmo, Reinhard Bauer, P.C. Schulze, Michael Lichtenauer, Iver Petersen, Dario Neri, Alexander Berndt & Christian Jung
Pulmonary hypertension (PH) is associated with vasoconstriction and remodelling. We studied lung tissue remodelling in a rat model of PH with special focus on histology and extracellular matrix (ECM) remodelling. After induction of PH by monocrotaline, lung tissue was analysed histologically, by gene expression analysis and immunofluorescence labelling of ED-A domain containing fibronectin (ED-A+ Fn), B domain containing tenascin-C (B+ Tn-C) as well as alpha-smooth muscle actin (α-SMA). Serum concentrations of ED-A+ Fn were determined...
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