Dicer, a new regulator of pluripotency exit and LINE-1 elements in mouse embryonic stem cells

Maxime Bodak, Daniel Cirera-Salinas, Jian Yu, Richard P. Ngondo & Constance Ciaudo
gene regulation network orchestrates processes ensuring the maintenance of cellular identity and genome integrity. Small RNAs generated by the RNAse III DICER have emerged as central players in this network. Moreover, deletion of Dicer in mice leads to early embryonic lethality. To better understand the underlying mechanisms leading to this phenotype, we generated Dicer-deficient mouse embryonic stem cells (mESCs). Their detailed characterization revealed an impaired differentiation potential, and incapacity to exit from the pluripotency state....
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