Oligoproline-Based Mono- and Bivalent Minigastrin and Octreotide Analogues: Synthesis, in Vitro, and in Vivo Characterization

Medullary thyroid cancer (MTC) and small cell lung cancer (SCLC) are both neuroendocrine tumours (NETs) with only very limited therapy options. The overexpression of peptide binding G-protein coupled receptors on the surface of cancer cells can be used for selective tumour targeting with radioactively labelled peptides for imaging and therapy. However, peptidic radioligands for the so-called peptide receptor radionuclide therapy (PRRT) often have limitations in terms of stability, specificity, bioavailability, and tumour tissue retention. The...
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