Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wound

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Matrix deposition is essential for wound repair, but when excessive, leads to hypertrophic scars and fibrosis. Here, we determined the interrelationship between the fibroblast transcriptome, the matrisome and the biomechanical properties of healing wounds. Using genetically-modified mice we show how a single diffusible factor, activin A, affects the healing process across scales. Bioinformatics analysis of wound fibroblast transcriptome data combined with biochemical and histopathological analyses of wounds and functional in vitro studies revealed that activin...
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