The targeted delivery of interleukin-2 to the carcinoembryonic antigen increases the intratumoral density of NK and CD8(+) T cell in an immunocompetent mouse model of colorectal cancer

Emanuele Puca, Caroline Schmitt-Koopmann, Marius Furter, Patrizia Murer, Philipp Probst, Manuel Dihr, Davor Bajic & Dario Neri
The recent success achieved by immune checkpoint inhibitors in the field of immuno-oncology has been less evident for the treatment of metastatic colorectal cancer (mCRC) patients. To date, cancer immunotherapy has been efficacious only in few patients bearing high mutational burden (less than 25%) mCRCs. In this Communication, we report the generation of a novel antibody cytokine fusion protein (termed Sm3E-mIL12) targeting the CRC-associated carcinoembryonic antigen (CEA). The antibody moiety bound avidly to CEA when...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.