Dataset as a basis for process modeling of twin-screw wet granulation: A parametric study of residence time distributions and granulation kinetics

Timo Plath, Carolin Korte, Rakulan Sivanesapillai & T. (Thomas) Weinhart
Twin-screw wet granulation is a crucial unit operation in shifting from pharmaceutical batch to continuous processes, but granulation kinetics as well as residence times are yet poorly understood. Experimental findings are highly dependent on screw configuration as well as formulation and therefore have limited universal validity. In the study underlying this dataset, an experimental design with a repetitive screw setup was conducted to measure the effect of specific feed load (SFL), liquid-to-solid ratio (L/S) and...
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