Catalyst Cascade Reactions in ‘One-Flow’ within a Compartmentalized, Green-Solvent ‘Digital Synthesis Machinery’ – End-to-End Green Process Design for Pharmaceuticals.

Eindhoven University of Technology, Department of Chemical Engineering and Chemistry Graz University of Technology, Institute of Process and Particle Engineering (IPPE) Delft University of Technology, Department of Biotechnology University of Bielefeld, France Faculty of Chemistry CNRS = National Center for Scientific Research (Centre National pour la Recherche Scientifique CNRS), LGPC unit University of Hull, Department of Chemistry and Biochemistry University of Cambridge & Graz Austria Department of Chemistry Microinnova Engineering GmbH
The ONE-FLOW project translates a ‘vertical hierarchy’ of chemical multistep synthesis with its complex machinery into a self-organising ‘horizontal hierarchy’ of a compartmentalized flow reactor system – a biomimetic digital flow cascade machinery with just one reactor passage. To keep the horizontal hierarchy manageable, orthogonality needs to be increased among the different consecutive reactions.
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