Data underlying the article: Chemoenzymatic Synthesis of Sialic Acid Derivatives Using Immobilized N-Acetylneuraminate Lyase in a Continuous Flow Reactor

Victor Bloemendal, S.J. (Sam) Moons, J.J.A. (Jurriaan) Heming, M. (Mohamed) Chayoua, O. (Olaf) Niesink, Jan van Hest, T.J. (Thomas) Boltje & F.P.J.T. (Floris) Rutjes
The synthesis of N-acetylneuraminic acid (Neu5Ac) derivatives is drawing more and more attention in glycobiology research because of the important role of sialic acids in e. g. cancer, bacterial, and healthy cells. Chemical preparation of these carbohydrates typically relies on multistep synthetic procedures leading to low overall yields. Herein we report a continuous flow process involving N-acetylneuraminate lyase (NAL) immobilized on Immobead 150P (Immobead-NAL) to prepare Neu5Ac derivatives. Batch experiments with Immobead-NAL showed equal activity...
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