Dendritic cells and antiviral defenses

Marc Dalod
The goal of our research is to identify new molecular pathways regulating the biology of DC subsets or more generally innate immune responses to viral infection. The model used is murine cytomegalovirus (MCMV) infection. The specific aims are 1) to determine the molecular bases regulating in vivo differentiation and anti-viral functions of DC subsets, 2) to investigate further NK cell anti-viral and immunoregulatory functions during viral infection, and 3) to identify viral molecules and cellular...

3 Related Works

Transcription profiling of Ikaros deficient plasmacytoid dendritic cells

Philippe Kastner
Ikaros is an important regulator of early dendritic cell development. To determine whether bone marrow plasmacytoid dendritic cells are affected by Ikaros decifiency, the transcription profilings of these cells has been compared to those of wild-type plasmacytoid cells.

Comparison of mouse dendritic cell subsets by genome-wide expression profiling

Marc Dalod, Robbins Scott, Doulaye Dembele, Philippe Kastner & Susan Chan
Spleen or lymph node resident DCs are subdivided into conventional DC (cDC) subsets (CD11b and CD8alpha in mouse; BDCA1 and BDCA3 in man) and plasmacytoid DCs (pDCs). It is currently unclear if these various DC populations belong to a unique hematopoietic lineage and if the subsets identified in the mouse and human systems are evolutionary homologs. To bring novel insights into these questions, we sought conserved genetic signatures for these DCs through the analysis of...

Dendritic cells and antiviral defenses

Marc Dalod
The goal of our research is to identify new molecular pathways regulating the biology of DC subsets or more generally innate immune responses to viral infection. The model used is murine cytomegalovirus (MCMV) infection. The specific aims are 1) to determine the molecular bases regulating in vivo differentiation and anti-viral functions of DC subsets, 2) to investigate further NK cell anti-viral and immunoregulatory functions during viral infection, and 3) to identify viral molecules and cellular...

Resource Types

  • Text
    3

Publication Year

  • 2010
    3

Registration Year

  • 2010
    3

Data Centers

  • INIST/CNRS - Standard-Based Infrastructure with Distributed Resources
    3