A Mild Method for the Cleavage of the 4-Picolyloxy Group with Magnesium under Neutral Conditions

Jianwei Zhu, Wenjun Miao, Lingling Bao, Tao Ji, Guo Tang, Pengxiang Xu & Yufen Zhao
A mild and efficient method for the selective hydrolysis of 4-picolyl esters with magnesium in methanol or water in the presence of other esters and sensitive protecting groups is described. 4-Picolyl aryl ethers and thioethers are also smoothly deprotected to give the corresponding phenols and thiophenols.