An Eficient One-Pot Synthesis of Macrocyclic Compounds Possessing Propargylamine Skeletons via Mannich Reaction

Tao Pang, Qinwan Yang, Meng Gao, Meng Wang & Anxin Wu
A new efficient method using the Mannich three-component reaction in one pot to synthesize [1+2+1]- and [2+4+2]-macrocyclic compounds possessing a propargylamine backbone was reported. Interestingly, 1,4-diazepane as a multiuse reagent played the part of a substrate to participate in the Mannich reaction and acted as a base to promote the Eglinton-Glaser dimerizations in the coordination processes simultaneously via a one-pot procedure. The target macrocycles were obtained in good yields.

6 Related Works

CCDC 848122: Experimental Crystal Structure Determination

Tao Pang, Qinwan Yang, Meng Gao, Meng Wang & Anxin Wu
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CCDC 832859: Experimental Crystal Structure Determination

Tao Pang, Qinwan Yang, Meng Gao, Meng Wang & Anxin Wu
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CCDC 815277: Experimental Crystal Structure Determination

Tao Pang, Qinwan Yang, Meng Gao, Meng Wang & Anxin Wu
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CCDC 815276: Experimental Crystal Structure Determination

Tao Pang, Qinwan Yang, Meng Gao, Meng Wang & Anxin Wu
Related Article: Tao Pang, Qinwan Yang, Meng Gao, Meng Wang, Anxin Wu|2011|Synlett||3046|doi:10.1055/s-0031-1289904

CCDC 815275: Experimental Crystal Structure Determination

Tao Pang, Qinwan Yang, Meng Gao, Meng Wang & Anxin Wu
Related Article: Tao Pang, Qinwan Yang, Meng Gao, Meng Wang, Anxin Wu|2011|Synlett||3046|doi:10.1055/s-0031-1289904

An Eficient One-Pot Synthesis of Macrocyclic Compounds Possessing Propargylamine Skeletons via Mannich Reaction

Tao Pang, Qinwan Yang, Meng Gao, Meng Wang & Anxin Wu
A new efficient method using the Mannich three-component reaction in one pot to synthesize [1+2+1]- and [2+4+2]-macrocyclic compounds possessing a propargylamine backbone was reported. Interestingly, 1,4-diazepane as a multiuse reagent played the part of a substrate to participate in the Mannich reaction and acted as a base to promote the Eglinton-Glaser dimerizations in the coordination processes simultaneously via a one-pot procedure. The target macrocycles were obtained in good yields.

Resource Types

  • Dataset
    6

Publication Year

  • 2012
    5
  • 2011
    1

Registration Year

  • 2014
    5
  • 2011
    1

Data Centers

  • The Cambridge Crystallographic Data Centre
    5
  • Thieme Chemistry
    1