Synthesis of Unsymmetrically Substituted 4,6,10-Trihydroxy-1,4,6,10-tetra­azaadamantanes via Intramolecular Cyclization of Tris(β-oximinoalkyl)amines

Artem N. Semakin, Alexey Yu. Sukhorukov, Yulia V. Nelyubina, Sema L. Ioffe & Vladimir A. Tartakovsky
The cyclotrimerization of oximino groups in unsymmetrically substituted tris(β-oximinoalkyl)amines was studied. A general approach to the synthesis of 4,6,10-trihydroxy-1,4,6,10-tetraazaadamantanes containing different substituents at bridgehead carbon atoms was developed from available aliphatic nitro compounds.

2 Related Works

CCDC 843973: Experimental Crystal Structure Determination

A.N. Semakin, A.Y. Sukhorukov, Y.V. Nelyubina, S.L. Ioffe & V.A. Tartakovsky
Related Article: A.N.Semakin, A.Y.Sukhorukov, Y.V.Nelyubina, S.L.Ioffe, V.A.Tartakovsky|2012|Synthesis|44|1095|doi:10.1055/s-0031-1289735

Synthesis of Unsymmetrically Substituted 4,6,10-Trihydroxy-1,4,6,10-tetra­azaadamantanes via Intramolecular Cyclization of Tris(β-oximinoalkyl)amines

Artem N. Semakin, Alexey Yu. Sukhorukov, Yulia V. Nelyubina, Sema L. Ioffe & Vladimir A. Tartakovsky
The cyclotrimerization of oximino groups in unsymmetrically substituted tris(β-oximinoalkyl)amines was studied. A general approach to the synthesis of 4,6,10-trihydroxy-1,4,6,10-tetraazaadamantanes containing different substituents at bridgehead carbon atoms was developed from available aliphatic nitro compounds.

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